Role of CHD5 in Human Cancers: 10 Years Later

Role of CHD5 in human cancers: 10 years later.

CHD5 was first identified because of its location on 1p36 in a region of frequent deletion in neuroblastomas. CHD5 (chromodomain-helicase-DNA-binding-5) is the fifth member of a family of chromatin remodeling proteins, and it probably functions by forming a nucleosome remodeling and deacetylation (NuRD) complex that regulates transcription of particular genes. CHD5 is preferentially expressed i...

ADHD: 10 Years Later

Estimates of children struggling with attention-deficit/hyperactivity disorder (ADHD) vary, but the Centers for Disease Control puts the number at a stunningly high 25 percent. Whatever the number, ADHD affects too many children at school, at home, and with their peers, and often persists into adulthood. The cause is as yet unknown, although genetic factors and their interaction with the enviro...

iPS Cells 10 Years Later

In 2006, Takahashi and Yamanaka reported the breakthrough discovery of induction of pluripotent stem cells from fibroblasts by a combination of defined factors. Ten years later, Cell editor João Monteiro brings together Shinya Yamanaka and Hans Schöler, one the original reviewers of the landmark study, to revisit the history behind the paper and its long-lasting legacy.

Security patterns: 10 years later

Reusing time-tested solutions rather than inventing ad-hoc quick fixes is a wellknown security principle. Architectural and design patterns represent proven techniques to package knowledge from software engineering experts in a reusable format. More importantly, the solution proposed by a pattern is known to be sound because it is time-tested—its strengths, weaknesses and possible drawbacks are...

The Krever Commission--10 years later.